BDBM50158850 CHEMBL3785434

SMILES NNC(=O)Cc1nnn[nH]1

InChI Key InChIKey=TWKUAKLZOIABHJ-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50158850   

TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataKi:  1.94E+3nMAssay Description:Competitive inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using 2-oxoglutarate as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of KDM4A (unknown origin) measured by antibody-based LANCE Ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using H3K9me3 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of full length human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using H3K4me3 (1 to 21 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 4.66E+4nMAssay Description:Inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using H3K9me3 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 4.66E+4nMAssay Description:Inhibition of KDM4A (unknown origin) measured by formaldehyde dehydrogenase (FDH)-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetLysine-specific demethylase 6B(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM6B (1043 residues) expressed in baculovirus infected sf9 cells using H3K27me3 (21 to 44 residues) subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2017
Entry Details Article
PubMed