BDBM50176521 5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxylic acid [1,3,4]thiadiazol-2-ylamide::CHEMBL200906

SMILES CN1C(=O)C(C(=O)Nc2nncs2)c2cc3occc3cc12

InChI Key InChIKey=OQMLSKSSPKAKJQ-UHFFFAOYSA-N

Data  13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50176521   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 40nMAssay Description:Inhibitory activity against PDE2 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.16E+4nMAssay Description:Inhibitory activity against PDE11 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE8B by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE8A by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE4D by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE4C by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
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Date in BDB:
11/10/2009
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TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE10 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE1 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
11/10/2009
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE3 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
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Date in BDB:
11/10/2009
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TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE5 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE9 by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
11/10/2009
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE4A by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50176521(5-methyl-6-oxo-6,7-dihydro-5H-furo[2,3-f]indole-7-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
11/10/2009
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