BDBM50182681 CHEMBL202621::N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-4-(4-morpholinyl)-2-butynamide

SMILES Fc1ccc(Nc2ncnc3ccc(NC(=O)C#CCN4CCOCC4)cc23)cc1Cl

InChI Key InChIKey=TURWKCNNQKWOTA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182681   

TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182681(N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolin...)
Affinity DataIC50: 31nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182681(N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolin...)
Affinity DataIC50: 86nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182681(N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolin...)
Affinity DataIC50: 173nMAssay Description:Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182681(N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolin...)
Affinity DataIC50: 229nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182681(N-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolin...)
Affinity DataIC50: 300nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed