BDBM50182696 CHEMBL202421::N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(dibutylamino)-2-butynamide

SMILES CCCCN(CCCC)CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1

InChI Key InChIKey=GHQPLJWMCNPRIH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50182696   

TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182696(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 17nMAssay Description:Inhibition of erbB1 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182696(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 49nMAssay Description:Inhibition of EGF stimulated human erbB1 autophosphorylation in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182696(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 67nMAssay Description:Inhibition of erbB2 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182696(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 73nMAssay Description:Inhibition of erbB4 fusion protein expressed in baculovirus by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50182696(N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]...)
Affinity DataIC50: 320nMAssay Description:Inhibition of HER stimulated human erbB autophosphorylation in MDA-MB-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed