BDBM50183851 (R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yl)methyl)-N,N-dimethylpyrrolidine-2-carboxamide::CHEMBL382822

SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCC[C@@H]1C(=O)N(C)C

InChI Key InChIKey=ZZBAYSXOXCZQAE-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50183851   

TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 450nMAssay Description:Inhibition of EGFR in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 450nMAssay Description:Inhibition of EGFR in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAPKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SAP kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SGKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50183851((R)-1-((4-(3-chloro-2-fluorophenylamino)-7-methoxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed