BDBM50205884 1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one::CHEMBL376455

SMILES O=C1N2CCNCC2c2ccccc12

InChI Key InChIKey=MHUTWQRLKOUUFX-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205884   

Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataKi:  630nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataEC50:  1.50E+3nMAssay Description:Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataKi:  4.54E+3nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataKi:  8.54E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205884(1,3,4,10b-tetrahydropyrazino[2,1-a]isoindol-6(2H)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed