BDBM50211444 CHEMBL245535::N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-2-oxoethyl)acetamide

SMILES CC(=O)NCC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12

InChI Key InChIKey=JDOKMDILBRSOLL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50211444   

TargetMitogen-activated protein kinase 8(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211444(N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yla...)
Affinity DataIC50: 28nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211444(N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yla...)
Affinity DataIC50: 46nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211444(N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yla...)
Affinity DataIC50: 551nMAssay Description:Inhibition of CDK2 by IMAP technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTranscription factor Jun(Human)
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50211444(N-(2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yla...)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of cJun translocation in IL-1-beta-stimulated A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed