BDBM50216688 2-cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide::CHEMBL225797

SMILES FC(F)(F)c1cccc(c1)-c1ccc(\C=C(/C#N)C(=O)Nc2cccc3ncccc23)o1

InChI Key InChIKey=UPXWENMZGDNXKC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50216688   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50216688(2-cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human recombinant SIRT2 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50216688(2-cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant SIRT3 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50216688(2-cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using fluorescent peptide substrate by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed