BDBM50219355 5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethyl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL399021

SMILES Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@H](CN2CCCC2)C1

InChI Key InChIKey=LSFLAQVDISHMNB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50219355   

TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 78nMAssay Description:Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 170nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 323nMAssay Description:Inhibition IGF1R phosphorylation in human MiaPaCa2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of IGF1R in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of IGF1R in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of IGF1R in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 4.24E+3nMAssay Description:Inhibition of IGF1R in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 4.68E+3nMAssay Description:Inhibition of IGF1R in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50219355(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-ylmethy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed