BDBM50242817 CHEMBL4087968::US20240150300, Compound Chidamide
SMILES Nc1ccc(F)cc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1
InChI Key InChIKey=WXHHICFWKXDFOW-UHFFFAOYSA-N
Data 42 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 51 hits for monomerid = 50242817
Affinity DataIC50: 67nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human HDAC2 using FLUOR-DE-LYS-Green as substrate incubated for 10 mins followed by substrate addition and measured after 3...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of C-terminal 6His-FLAG-tagged human recombinant HDAC1 (1 to 482 residues) expressed in Sf9 cells using Ac-peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Inhibition of HDAC1 (unknown origin) using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysisMore data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Human)
Hunan University of Science and Technology
Curated by ChEMBL
Hunan University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
TargetPolyamine deacetylase HDAC10(Human)
Hunan University of Science and Technology
Curated by ChEMBL
Hunan University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant HDAC10 incubated for 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant HDAC1 incubated for 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Human recombinant HDAC family proteins with His and GST tags were expressed using insect baculovirus expression system, and a biologically active HDA...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant HDAC2 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant His-tagged HDAC1 (482 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant human His tagged HDAC1 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Human)
Beijing University of Chemical Technology
Curated by ChEMBL
Beijing University of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 234nMAssay Description:Inhibition of recombinant human HDAC3/NCOR1 assessed as decrease in deacetylation of FLUOR DE LYS SIRT1 substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human HDAC1 using SIRT1 as substrate incubated for 10 mins followed by substrate addition and measured after 30 mins by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant His-tagged HDAC2 (1 to 582 residues) expressed in baculovirus infected insect cells using FLUOR DE LYS Green as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant human HDAC2 assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of human recombinant HDAC2 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 432nMAssay Description:Inhibition of human recombinant HDAC11 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 479nMAssay Description:Inhibition of HDAC2 in human HeLa cells nuclear extract using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysi...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 733nMAssay Description:Inhibition of human recombinant HDAC8 incubated for 17 hrsMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 864nMAssay Description:Inhibition of recombinant human HDAC1 using a fluorogenic substrate by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using fluor-de-lys-green as substrate preincubated for 10 mins followed by substrate addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract assessed as decrease in deacetylation of FLUOR DE LYS Green substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of HDAC in human HeLa cell extract using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC9 in human HeLa cells nuclear extract using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC11 in human HeLa cells nuclear extract using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analys...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC6 (unknown origin) using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC4 in human HeLa cells nuclear extract using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HDAC7 in human HeLa cells nuclear extract using BocLys(acetyl)-AMC as substrate incubated for 1 hr by fluorescence plate reader analysi...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in Baculovirus insect cell expression system using [3H]-metabolically labeled acetylated histone subs...More data for this Ligand-Target Pair
Affinity DataIC50: 7.11E+3nMAssay Description:Inhibition of human recombinant HDAC6 using Fluor de Lys-Green as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of human recombinant His-tagged HDAC6 expressed in baculovirus infected insect cells using FLUOR DE LYS SIRT1 as substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of recombinant human His tagged HDAC6 expressed in baculovirus infected insect cells assessed as decrease in deacetylation of FLUOR DE LYS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Human recombinant HDAC family proteins with His and GST tags were expressed using insect baculovirus expression system, and a biologically active HDA...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataKd: 1.83E+4nMAssay Description:Binding affinity to HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human recombinant HDAC2 preincubated for 10 mins followed by addition of substrate fluor De Lys green measured after 30 mins by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC7 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC5 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC4 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant HDAC9 incubated for 17 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human HDAC8 assessed as decrease in deacetylation of FLUOR DE LYS substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Shanghai Institute of Pharmaceutical Industry
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of recombinant human ERG expressed in HEK293 cells after 9 mins by patch clamp methodMore data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Human)
Beijing University of Chemical Technology
Curated by ChEMBL
Beijing University of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of human recombinant HDAC3/NCOR1 complex preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measure...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of human recombinant HDAC1 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant HDAC6 preincubated for 10 mins followed by addition of substrate fluor De Lys SIRT1 deacetylase measured after 30 min...More data for this Ligand-Target Pair
