BDBM50266792 CHEMBL4075255::US11358936, Compound 4-7

SMILES NCc1ccnc(OC2CCCCC2)c1

InChI Key InChIKey=ULGNIWUOIJPCIG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50266792   

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50266792(CHEMBL4075255 | US11358936, Compound 4-7)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2022
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50266792(CHEMBL4075255 | US11358936, Compound 4-7)
Affinity DataIC50: 850nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50266792(CHEMBL4075255 | US11358936, Compound 4-7)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50266792(CHEMBL4075255 | US11358936, Compound 4-7)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetProtein-lysine 6-oxidase(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50266792(CHEMBL4075255 | US11358936, Compound 4-7)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed