BDBM50269040 1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine::CHEMBL496013

SMILES C(c1ccccc1)c1nnc(N2CCN(CC2)c2ccccc2)c2ccccc12

InChI Key InChIKey=PMNLMFUHSIYHHB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50269040   

TargetSmoothened homolog(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269040(1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine | C...)
Affinity DataIC50: 414nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 1 nM 3-chloro-4,7-difluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269040(1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine | C...)
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from mous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269040(1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine | C...)
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of Smoothened receptor in mouse TM3 cells transfected with pTA-8xGli-Luc reporter gene assessed as inhibition of 25 nM 3-chloro-4,7-difluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50269040(1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine | C...)
Affinity DataIC50: 4.24E+3nMAssay Description:Displacement of [3H]3-chloro-4,7-difluoro-N-(4-methoxy-3-(pyridin-4-yl)benzyl)-N-(4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed