BDBM50277640 CHEMBL485351::N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide

SMILES CCN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)CC)cc2)n1

InChI Key InChIKey=SUIPNNKRHBDYHW-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277640   

TargetAurora kinase A(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277640(N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyr...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277640(N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyr...)
Affinity DataIC50: 25nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277640(N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyr...)
Affinity DataKi:  25nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed