BDBM50314738 CHEMBL1089182::N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}ethyl)-1-pyridin-2-yl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

SMILES CCOc1ccc(cc1)C(=O)NCCNC(=O)c1cn(nc1C(F)(F)F)-c1ccccn1

InChI Key InChIKey=DVIVYBXEYFCOEC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50314738   

TargetDiacylglycerol O-acyltransferase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314738(N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}ethyl)-1-pyr...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human DGAT1 expressed in baculovirus infected Sf9 cells using [14C]oleoyl-CoA after 15 mins by TLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50314738(N-(2-{[(4-Ethoxyphenyl)carbonyl]amino}ethyl)-1-pyr...)
Affinity DataIC50: 91nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as suppression of [14C]triglyceride accumulation pretreated for 20 mins before [14C]oleic acid chal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed