BDBM50327905 CHEMBL1257177::trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpteridin-7(8H)-one

SMILES COc1ccc(cn1)-c1nc2c(C)nc(N)nc2n([C@H]2CC[C@H](O)CC2)c1=O

InChI Key InChIKey=FICWXAPOGIEJJR-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327905   

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327905(trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6...)
Affinity DataKi:  6.80nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327905(trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6...)
Affinity DataIC50: 14.3nMAssay Description:Inhibition of AKT in human BT20 cells assessed as inhibition of S473 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed