BDBM50327964 CHEMBL1256418::N-(4-(4-amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-5,7-dimethylbenzo[d]oxazol-2-amine

SMILES CN1CCN(CC1)[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Nc3nc4cc(C)cc(Br)c4o3)c(F)c2)c2c(N)ncnc12

InChI Key InChIKey=HTKPXHSTHMGWJY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327964   

LigandPNGBDBM50327964(N-(4-(4-amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 93nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50327964(N-(4-(4-amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 94nMAssay Description:Inhibition of Homo sapiens (human) recombinant C-terminal GST-tagged IGF1R expressed in baculovirus infected Sf21 cells by homogeneous time-resolved ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50327964(N-(4-(4-amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 94nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50327964(N-(4-(4-amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 6.25E+4nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed