BDBM50328307 CHEMBL1258825::N-(3-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propoxy)phenyl)acetamide

SMILES CC(=O)Nc1cccc(OCC(O)CNC2CCN(CC2)c2ncnc3scc(-c4ccccc4)c23)c1

InChI Key InChIKey=FYHRQQABWWQSSJ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50328307   

TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328307(N-(3-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimid...)
Affinity DataKi:  85nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328307(N-(3-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimid...)
Affinity DataIC50: 107nMAssay Description:Antagonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as inhibition of isoproterenol-induced cyclic AMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328307(N-(3-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimid...)
Affinity DataKi:  117nMAssay Description:Displacement of [125I]-cyanopindolol from human adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
4Sc

Curated by ChEMBL
LigandPNGBDBM50328307(N-(3-(2-hydroxy-3-(1-(5-phenylthieno[2,3-d]pyrimid...)
Affinity DataKi:  2.02E+3nMAssay Description:Agonist activity at human recombinant adrenergic beta-1 receptor expressed in CHO cells assessed as cyclic AMP formation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed