BDBM50328378 CHEMBL1258829::ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-morpholino-4-phenyl-7-propylpyrrolo[1,2-b]pyridazine-5-carboxylate

SMILES CCCc1c(-c2nc(no2)C2CCCC2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1

InChI Key InChIKey=DFLCDDOFQUFQBZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328378   

TargetDiacylglycerol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328378(ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-mor...)
Affinity DataIC50: 30nMAssay Description:Inhibition of DGAT1 in human Caco-2 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328378(ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-mor...)
Affinity DataIC50: 48nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328378(ethyl 6-(3-cyclopentyl-1,2,4-oxadiazol-5-yl)-2-mor...)
Affinity DataIC50: 230nMAssay Description:Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed