BDBM50328389 CHEMBL1257330::ethyl 7-(2-hydroxyethyl)-2-morpholino-4-phenyl-6-(3-(pyrrolidin-1-yl)-1,2,4-oxadiazol-5-yl)pyrrolo[1,2-b]pyridazine-5-carboxylate

SMILES CCOC(=O)c1c(c(CCO)n2nc(cc(-c3ccccc3)c12)N1CCOCC1)-c1nc(CCO)no1

InChI Key InChIKey=ZECYWJRNPDQQDM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328389   

TargetDiacylglycerol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328389(ethyl 7-(2-hydroxyethyl)-2-morpholino-4-phenyl-6-(...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328389(ethyl 7-(2-hydroxyethyl)-2-morpholino-4-phenyl-6-(...)
Affinity DataIC50: 260nMAssay Description:Inhibition of DGAT1 in human Caco-2 cells after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetSterol O-acyltransferase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50328389(ethyl 7-(2-hydroxyethyl)-2-morpholino-4-phenyl-6-(...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed