BDBM50331034 2-phenyl-N-(1-(pyridin-2-yl)propyl)quinoline-4-carboxamide::CHEMBL1277892

SMILES CCC(NC(=O)c1cc(nc2ccccc12)-c1ccccc1)c1ccccn1

InChI Key InChIKey=ZUKHCFDOVYFUHP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50331034   

TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50331034(2-phenyl-N-(1-(pyridin-2-yl)propyl)quinoline-4-car...)
Affinity DataIC50: 5.20nMAssay Description:Displacement of [125I]-MePhe7-NKB from human NK3 receptor expressed in CHO cells after 90 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50331034(2-phenyl-N-(1-(pyridin-2-yl)propyl)quinoline-4-car...)
Affinity DataIC50: 900nMAssay Description:Antagonist activity against human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced increase of intracellular calcium le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL
LigandPNGBDBM50331034(2-phenyl-N-(1-(pyridin-2-yl)propyl)quinoline-4-car...)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against human NK3 receptor expressed in HEK293 cells assessed as inhibition of MePhe7-NKB-induced increase of intracellular calci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed