BDBM50332072 CHEMBL1287945::N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 73

SMILES Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12

InChI Key InChIKey=UNKZYKXHTPRCOC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332072   

TargetMitogen-activated protein kinase 10(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332072(N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(n...)
Affinity DataIC50: 1.00E+4nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 8(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332072(N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(n...)
Affinity DataIC50: 1.00E+4nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 8(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332072(N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(n...)
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of recombinant JNK1 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM50332072(N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(n...)
Affinity DataIC50: 4.25E+4nMAssay Description:Inhibition of recombinant JNK3 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50332072(N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(n...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant JNK2 after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed