BDBM50337905 1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethanamine::CHEMBL1684051::US10562878, Compound 19 E2

SMILES CC(N)C1(CCCCC1)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=VRVDHYBVMARMIQ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50337905   

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 107nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]serotonin reuptake at human recombinant SERT expressed in LLC-PK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 398nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 696nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 735nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human serotonin reuptake transporter was assayed using the recombinant human serotonin transporter expressed in HEK-293 cells. HEK-293 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of [3H]dopamine reuptake at human recombinant DAT expressed in COS-7 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of human dopamine reuptake transporter was assayed using the recombinant human dopamine transporter expressed in either CHO-K1 or HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetSodium-dependent noradrenaline transporter(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human recombinant NET expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Sunovion Pharamceuticals

US Patent
LigandPNGBDBM50337905(1-(1-(4-(trifluoromethoxy)phenyl)cyclohexyl)ethana...)
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of human norepinephrine reuptake transporter was assayed using the recombinant human norepinephrine transporter expressed in either HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent