BDBM50338027 (S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)propan-1-one::CHEMBL1684295

SMILES Clc1cc2nc([nH]c2cc1Cl)[C@@H]1CCCN1C(=O)CCN1CCC(CC1)c1nc(no1)-c1ccccn1

InChI Key InChIKey=OJCDGMHBQVTOKH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50338027   

TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of mouse PrCPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human PrCPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 173nMAssay Description:Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetLysosomal Pro-X carboxypeptidase(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50338027((S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)py...)
Affinity DataIC50: 173nMAssay Description:Inhibition of PrCP in mouse plasma assessed as angiotensin 3 cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed