BDBM50376057 CHEMBL259141::US10227357, Compound P-0541

SMILES NC1CCN(CC1)c1ncnc2[nH]ccc12

InChI Key InChIKey=SOYJTCRGELSHIV-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50376057   

TargetRAC-beta serine/threonine-protein kinase(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50376057(CHEMBL259141 | US10227357, Compound P-0541)
Affinity DataIC50: 180nMAssay Description:Inhibition of PKBbeta recombinant by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376057(CHEMBL259141 | US10227357, Compound P-0541)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50376057(CHEMBL259141 | US10227357, Compound P-0541)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of GSK3-beta in human PC3M cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM50376057(CHEMBL259141 | US10227357, Compound P-0541)
Affinity DataKi:  1.05E+5nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent