BDBM50397996 CHEMBL2180403::Roche-Dataset for PDE10A, Compound 822::US8703768, 24

SMILES CNC(=O)c1ccncc1NC(=O)c2c(ccc(n2)C3CC3)Nc4cncnc4

InChI Key InChIKey=QJUBZPIVEQSLKB-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50397996   

LigandPNGBDBM50397996(CHEMBL2180403 | US8703768, 24 | Roche-Dataset for ...)
Affinity DataIC50: 13.7nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

LigandPNGBDBM50397996(CHEMBL2180403 | US8703768, 24 | Roche-Dataset for ...)
Affinity DataIC50: 14nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50397996(CHEMBL2180403 | US8703768, 24 | Roche-Dataset for ...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length PDE10A using [3H]cGMP as substrate after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed