BDBM50408818 CHEMBL5287134

SMILES CN(C)C[C@H]1CN(CC[C@]1(O)c1cccc(O)c1)C(=O)Cc1cc(F)c(F)cc1F

InChI Key InChIKey=JMDFENKDWRFUQU-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50408818   

TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408818(CHEMBL5287134)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408818(CHEMBL5287134)
Affinity DataKi:  54nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408818(CHEMBL5287134)
Affinity DataEC50:  110nMAssay Description:Agonist activity at MOR (unknown origin) expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408818(CHEMBL5287134)
Affinity DataEC50:  500nMAssay Description:Agonist activity at KOR (unknown origin) expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50408818(CHEMBL5287134)
Affinity DataKi:  3.57E+3nMAssay Description:Displacement of [3H]-DPDPE from human DOR expressed in CHO cell membranes measured after 2 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed