BDBM50526287 CHEMBL4525939
SMILES Clc1cc(NCC2CC2)c2ncc(-c3ccc4[nH]ncc4c3)n2n1
InChI Key InChIKey=FLFMYUGDCXTOQI-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50526287
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 303nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dis...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of tunicamycin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1u...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
University of Leicester
Curated by ChEMBL
University of Leicester
Curated by ChEMBL
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP...More data for this Ligand-Target Pair