BDBM513042 (S) N-(1-hydroxypentan-2-yl)-6-((5-methyl-3-(6-methylpyridin-3-yl)isoxazol-4-yl)methoxy)nicotinamide::US11091471, Example 4::US20240279218, Example 4

SMILES CCC[C@@H](CO)NC(=O)c1ccc(OCc2c(C)onc2-c2ccc(C)nc2)nc1

InChI Key InChIKey=QMARBOVOPHNZOR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 513042   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513042((S) N-(1-hydroxypentan-2-yl)-6-((5-methyl-3-(6-met...)
Affinity DataKi:  7.30nMAssay Description:Electrophysiological experiments were performed on days 3 to 5 after the micro-injection of mRNA. During the experiment the oocytes were constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM513042((S) N-(1-hydroxypentan-2-yl)-6-((5-methyl-3-(6-met...)
Affinity DataKi:  7.30nMAssay Description:The affinity of compounds at GABAA receptor subtypes was measured by competition for [3H]flumazenil (85 Ci/mmol; Roche) binding to HEK293 cells expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2024
Entry Details
US Patent