BDBM53484 6-Benzothiazol-2-yl-1-ethyl-2-[2-(methyl-phenyl-amino)-vinyl]-3-phenyl-3H-benzoimidazol-1-ium::MLS001207496::N-[(E)-2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-2-benzimidazol-3-iumyl]ethenyl]-N-methylaniline;iodide::N-[(E)-2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-benzimidazol-3-ium-2-yl]ethenyl]-N-methyl-aniline;iodide::N-[(E)-2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenylbenzimidazol-3-ium-2-yl]ethenyl]-N-methylaniline;iodide::O-acyl oxime isatin derivative, 63::SMR000504738::[(E)-2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-benzimidazol-3-ium-2-yl]vinyl]-methyl-phenyl-amine;iodide::cid_5719375

SMILES CC[n+]1c(\C=C\N(C)c2ccccc2)n(-c2ccccc2)c2ccc(cc12)-c1nc2ccccc2s1

InChI Key InChIKey=OTHITMYLBRCVIT-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 53484   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 200nMAssay Description:Inhibition of AKT in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 250nMAssay Description:Inhibition of AKT in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 277nMAssay Description:Inhibition of AKT in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 357nMAssay Description:Inhibition of AKT in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 415nMAssay Description:Inhibition of AKT in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Knight Cancer Institute

Curated by ChEMBL
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 2.84E+3nMAssay Description:Inhibition of AKT in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 7.42E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 9.83E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 1.32E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetStreptokinase A(Streptococcus pyogenes M1 GAS)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataEC50:  1.33E+4nMAssay Description:Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2011
Entry Details
PCBioAssay
TargetG-protein coupled receptor 55(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataEC50:  3.20E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Mouse)
Brigham and Women'S Hospital

LigandPNGBDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 5.00E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition activity and selectivity for UCH-L1 and UCH-L3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2011
Entry Details Article
PubMed