BDBM538108 US11253516, Example 10

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=MPISIZFSGAZROV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 538108   

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human EGFR del19/T790M/C797S mutant using ATP-labelled peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.200nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 0.700nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Korea Research Institute of Chemical Technology

US Patent
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 4nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM538108(US11253516, Example 10)
Affinity DataIC50: 430nMAssay Description:Inhibition of human wild type EGFR using ATP-labelled peptide substrate by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed