BDBM59117 CHEMBL151430::Hymenialdisine, 11b

SMILES Nc1ncc([nH]1)C1CCNC(=O)c2[nH]c(Br)c(Br)c12

InChI Key InChIKey=MRMGABUTBNWSLA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 59117   

TargetMitogen-activated protein kinase 1(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM59117(CHEMBL151430 | Hymenialdisine, 11b)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandPNGBDBM59117(CHEMBL151430 | Hymenialdisine, 11b)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM59117(CHEMBL151430 | Hymenialdisine, 11b)
Affinity DataIC50: 8.15E+3nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM59117(CHEMBL151430 | Hymenialdisine, 11b)
Affinity DataIC50: 8.86E+3nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Genomics Institute of The Novartis Research Foundation

LigandPNGBDBM59117(CHEMBL151430 | Hymenialdisine, 11b)
Affinity DataIC50: 1.00E+4nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed