BDBM62324 4-[4-(1-acetylindolin-5-yl)sulfonylpiperazino]benzonitrile::4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]-1-piperazinyl]benzonitrile::4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzonitrile::4-[4-[(1-ethanoyl-2,3-dihydroindol-5-yl)sulfonyl]piperazin-1-yl]benzenecarbonitrile::MLS-0425665.0001::cid_44251470

SMILES CC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C#N

InChI Key InChIKey=JZCBZZIWVBWSLX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 62324   

TargetNucleotide-binding oligomerization domain-containing protein 1(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM62324(4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]pip...)
Affinity DataIC50: 5.87E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
TargetNucleotide-binding oligomerization domain-containing protein 1(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM62324(4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]pip...)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTumor necrosis factor(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM62324(4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]pip...)
Affinity DataIC50: 8.79E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM62324(4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]pip...)
Affinity DataIC50: 9.24E+3nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM62324(4-[4-[(1-acetyl-2,3-dihydroindol-5-yl)sulfonyl]pip...)
Affinity DataIC50: 9.24E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay