BDBM65243 US9522888, 573

SMILES N[C@]1(COP(O)(O)=O)CC[C@@H](C1)c1ccc2C[C@H](CCc3ccccc3)CCc2c1

InChI Key InChIKey=ZKEVQSHAPMPWHN-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 65243   

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM65243(US9522888, 573)
Affinity DataIC50: 55nMpH: 7.5 T: 2°CAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1x10^9 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM65243(US9522888, 573)
Affinity DataEC50:  55nMT: 2°CAssay Description:hS1P1/CHO cells were plated into BD Amine 384-well plates the day before the assay. On the day of the assay, growth medium was removed and replaced w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM65243(US9522888, 573)
Affinity DataEC50:  55nMT: 2°CAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM65243(US9522888, 573)
Affinity DataEC50: >625nMT: 2°CAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
US Patent