BDBM66782 1-(4-chlorophenyl)-3-[2-(4-methyl-1-piperazinyl)ethyl]urea::1-(4-chlorophenyl)-3-[2-(4-methylpiperazin-1-yl)ethyl]urea::1-(4-chlorophenyl)-3-[2-(4-methylpiperazino)ethyl]urea::MLS001197592::N-(4-chlorophenyl)-N'-[2-(4-methylpiperazin-1-yl)ethyl]urea::SMR000559951::cid_22430294

SMILES CN1CCN(CCNC(=O)Nc2ccc(Cl)cc2)CC1

InChI Key InChIKey=JXXNUZHEJSGKMM-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 66782   

TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM66782(N-(4-chlorophenyl)-N'-[2-(4-methylpiperazin-1-...)
Affinity DataIC50: 1.59E+3nMAssay Description:Allosteric antagonist activity at human CB1 receptor expressed in CHO-RD-HGA16 cells overexpressing Galpha16 assessed as inhibition of CP55940-stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM66782(N-(4-chlorophenyl)-N'-[2-(4-methylpiperazin-1-...)
Affinity DataIC50: 7.94E+3nMAssay Description:Allosteric antagonist activity at human CB1 receptor expressed in HEK293 cell membrane assessed as inhibition of CP55940-stimulated [35S]GTPgammaS bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM66782(N-(4-chlorophenyl)-N'-[2-(4-methylpiperazin-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO-RD-HGA16 cells overexpressing Galpha16 assessed as inhibition of CP55940-stimulated calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM66782(N-(4-chlorophenyl)-N'-[2-(4-methylpiperazin-1-...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay