BDBM78336 (6E)-6-[4-(3-pyridinylmethylamino)-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone::(6E)-6-[4-(3-pyridylmethylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one::(6E)-6-[4-(pyridin-3-ylmethylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one::2-{4-[(Pyridin-3-ylmethyl)-amino]-quinazolin-2-yl}-phenol::CHEMBL1328065::MLS001043268::SMR000415065::cid_6097933
SMILES Oc1ccccc1-c1nc(NCc2cccnc2)c2ccccc2n1
InChI Key InChIKey=MTMNCZKFTUQNJT-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 78336
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of recombinant human EGFR d746-750/T790M/C797S mutant using poly-Glu-Tyr (4:1) as substrate after 2 hrs in presence of [gamma-33P]-ATP by ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of human EGFR del19/T790M/C797S mutant assessed as enzyme remaining activity using poly-Glu-Tyr peptide substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
TargetCell division related protein kinase 2(Leishmania major)
Montclair State University
Curated by ChEMBL
Montclair State University
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Leishmania major CRK3 expressed in Escherichia coli BL21 (DE3) using 5FAM-GGGRSPGRRRRK-OH as substrate after 60 mins by IMAP assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of wild type recombinant N-terminal GST-tagged human EGFR catalytic domain expressed in Sf9 insect cells using poly-Glu-Tyr (4:1) as subst...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
H. R. Patel Institute of Pharmaceutical Education and Research
Curated by ChEMBL
Affinity DataIC50: 2.43E+4nMAssay Description:Inhibition of human wild type EGFR assessed as enzyme remaining activity using poly-Glu-Tyr peptide substrate incubated for 2 hrs in presence of [gam...More data for this Ligand-Target Pair
TargetMitochondrial import inner membrane translocase subunit TIM10(Baker's yeast)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 6.05E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair