BDBM97402 Orexin receptor antagonist 34::US20130102619, 34

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccc(F)cc1-c1ncccn1)Oc1cc(ccn1)C#N

InChI Key InChIKey=DVQKBFBIBGIHAF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 97402   

TargetOrexin receptor type 2(Human)
TBA

US Patent
LigandPNGBDBM97402(Orexin receptor antagonist 34 | US20130102619, 34)
Affinity DataKi:  3.5nMAssay Description:The inhibition constant (Ki) is determined using a radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-14...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2013
Entry Details
US Patent

TargetOrexin receptor type 2(Rat)
TBA

US Patent
LigandPNGBDBM97402(Orexin receptor antagonist 34 | US20130102619, 34)
Affinity DataIC50: 48nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are grown in Iscove's modified DMEM containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2013
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
TBA

US Patent
LigandPNGBDBM97402(Orexin receptor antagonist 34 | US20130102619, 34)
Affinity DataKi:  868nMAssay Description:The inhibition constant (Ki) is determined using a radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-14...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2013
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
TBA

US Patent
LigandPNGBDBM97402(Orexin receptor antagonist 34 | US20130102619, 34)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are grown in Iscove's modified DMEM containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2013
Entry Details
US Patent