BDBM50166903 4-Cyano-N-{(R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide::CHEMBL372205::Lecozotan

SMILES C[C@H](CN(C(=O)c1ccc(cc1)C#N)c1ccccn1)N1CCN(CC1)c1cccc2OCCOc12

InChI Key InChIKey=NRPQELCNMADTOZ-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50166903   

Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  1.60nMAssay Description:Displacement of 8-OH-DPAT from human 5-hydroxytryptamine 1A receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataIC50: 42nMAssay Description:In vitro inhibition of 8-OH-DPAT-induced [35S]GTP-gamma-S, binding to 5-HT1A receptor/G protein complex in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Wyeth

Curated by PDSP Ki Database
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  248nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Wyeth

Curated by PDSP Ki Database
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wyeth

Curated by PDSP Ki Database
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataKi:  1.55E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2012
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50166903(CHEMBL372205 | Lecozotan | 4-Cyano-N-{(R)-2-[4-(2,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed