BDBM10222 4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate::BI-9C4::Burnham Institute Compound 8

SMILES Clc1ccc(OC(=O)c2csc(n2)C2COc3ccccc3O2)cc1

InChI Key InChIKey=MVKZURMOBYUBHT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 10222   

TargetCaspase-3(Homo sapiens (Human))
Burnham Institute

LigandPNGBDBM10222(4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl...)
Affinity DataIC50:  7.40E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Burnham Institute

LigandPNGBDBM10222(4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl...)
Affinity DataIC50: >2.00E+5nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Burnham Institute

LigandPNGBDBM10222(4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl...)
Affinity DataIC50: >2.00E+5nMAssay Description:Fluorescent assays were carried out in black 96-well plates. Caspase activity was monitored using a Labsystem Fluoroskan II spectrofluorometer with a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed