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BDBM102447 US8536165, 4

SMILES: Cc1ccc(Nc2ccc(nc2)-c2cccc(c2)C(F)(F)F)c(c1)C(O)=O

InChI Key: InChIKey=BQLVBLBIXTYOHY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM102447
PNG
(US8536165, 4)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2cccc(c2)C(F)(F)F)c(c1)C(O)=O
Show InChI InChI=1S/C20H15F3N2O2/c1-12-5-7-18(16(9-12)19(26)27)25-15-6-8-17(24-11-15)13-3-2-4-14(10-13)20(21,22)23/h2-11,25H,1H3,(H,26,27)
PDB
MMDB

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PC sid
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Similars

US Patent
n/an/a 98n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...


US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair