BindingDB logo
myBDB logout

BDBM102477 US8536165, 74

SMILES: Cc1cc(Nc2ccc(cc2C(O)=O)C2CC2)cnc1-c1ccccc1

InChI Key: InChIKey=CBPGAIXEMSNWCD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 102477   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM102477
PNG
(US8536165, 74)
Show SMILES Cc1cc(Nc2ccc(cc2C(O)=O)C2CC2)cnc1-c1ccccc1
Show InChI InChI=1S/C22H20N2O2/c1-14-11-18(13-23-21(14)16-5-3-2-4-6-16)24-20-10-9-17(15-7-8-15)12-19(20)22(25)26/h2-6,9-13,15,24H,7-8H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...


US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair