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BDBM103709 US8563553, 134

SMILES: Nc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)C1CC1

InChI Key: InChIKey=ZKJBFFVDOXZLHA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 103709   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))
BDBM103709
PNG
(US8563553, 134)
Show SMILES Nc1nccc(n1)-c1nc([nH]c1-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1Cl)C1CC1
Show InChI InChI=1S/C22H17ClF2N6O2S/c23-17-12(3-1-6-15(17)31-34(32,33)20-13(24)4-2-5-14(20)25)18-19(16-9-10-27-22(26)28-16)30-21(29-18)11-7-8-11/h1-6,9-11,31H,7-8H2,(H,29,30)(H2,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a7.5n/a



Novartis AG

US Patent


Assay Description
Raf/Mek amplified luminescence proximity homogeneous assay.


US Patent US8563553 (2013)


BindingDB Entry DOI: 10.7270/Q2ZP44R7
More data for this
Ligand-Target Pair