BDBM103727 US10112907, Example 00033::US10206907, Compound 200::US10708263, Compound 1::US10766894, Compound TABLE 1.18::US10919890, Compound 1::US10961228, Example Filgotinib::US11000528, Cpd # 1::US11203595, TABLE 1.18::US11279699, Compound Filgotinib::US8563545, 1

SMILES: O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1

InChI Key: InChIKey=RIJLVEAXPNLDTC-UHFFFAOYSA-N

Data: 117 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 176 hits for monomerid = 103727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	41.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	79.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	86.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	376	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	73.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	814	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [831-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154] ()	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	47.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 [866-1154] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 [811-1124] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [888-1187] (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Human)	BDBM103727 (US8563545, 1 | US10112907, Example 00033 | US10206...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	644	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair