BDBM103961 ATX inhibitor 10::Disubstituted aryl-Me ATX inhibitor 3::Monosubstituted aryl-Me ATX inhibitor 5

SMILES CN1CCN(CC1)C1=NC(=O)\C(S1)=C\c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=BSGZTQWZIBOTMJ-LCYFTJDESA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 103961   

TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mus musculus)
The University Of Tokyo

LigandPNGBDBM103961(ATX inhibitor 10 | Disubstituted aryl-Me ATX inhib...)
Affinity DataIC50:  180nMMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM103961(ATX inhibitor 10 | Disubstituted aryl-Me ATX inhib...)
Affinity DataIC50:  180nMAssay Description:Inhibition of ATX (unknown origin) expressed in human HEK293 cells using TG-mTMP as substrate after 2 hrs by fluorescence based plate reader assayMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mus musculus)
The University Of Tokyo

LigandPNGBDBM103961(ATX inhibitor 10 | Disubstituted aryl-Me ATX inhib...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activities of hit compounds towards ENPP1-5 were calculated using pNP-TMP, and the inhibitory activities of hit compounds towards ENPP6 an...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mus musculus)
The University Of Tokyo

LigandPNGBDBM103961(ATX inhibitor 10 | Disubstituted aryl-Me ATX inhib...)
Affinity DataIC50:  640nMAssay Description:Inhibitory activities of hit compounds towards ENPP1-5 were calculated using pNP-TMP, and the inhibitory activities of hit compounds towards ENPP6 an...More data for this Ligand-Target Pair