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BDBM104247 US8575145, 124

SMILES: F[C@@H]1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2cc(Cl)ccn12

InChI Key: InChIKey=PHJNQZCUTKCIGD-XKYSEJONNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104247   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM104247
PNG
(US8575145, 124)
Show SMILES F[C@@H]1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2cc(Cl)ccn12
Show InChI InChI=1/C20H17ClFN5O/c21-13-7-9-27-18(10-13)25-26-20(27)15-5-4-12-2-1-3-17(19(12)24-15)28-16-6-8-23-11-14(16)22/h1-5,7,9-10,14,16,23H,6,8,11H2/t14-,16?/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+3n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM104247
PNG
(US8575145, 124)
Show SMILES F[C@@H]1CNCCC1Oc1cccc2ccc(nc12)-c1nnc2cc(Cl)ccn12
Show InChI InChI=1/C20H17ClFN5O/c21-13-7-9-27-18(10-13)25-26-20(27)15-5-4-12-2-1-3-17(19(12)24-15)28-16-6-8-23-11-14(16)22/h1-5,7,9-10,14,16,23H,6,8,11H2/t14-,16?/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 31n/an/an/an/a7.422



Array BioPharma Inc

US Patent


Assay Description
The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...


US Patent US8575145 (2013)


BindingDB Entry DOI: 10.7270/Q2M90797
More data for this
Ligand-Target Pair