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BDBM105003 US8575364, 12

SMILES: COc1ccc(cc1OC1CNC1)-c1ccc(F)c(C)c1

InChI Key: InChIKey=KDCWDEPJOSMEIH-UHFFFAOYSA-N

Data: 2 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 105003   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM105003
PNG
(US8575364, 12)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C17H18FNO2/c1-11-7-12(3-5-15(11)18)13-4-6-16(20-2)17(8-13)21-14-9-19-10-14/h3-8,14,19H,9-10H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
770n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...


US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM105003
PNG
(US8575364, 12)
Show SMILES COc1ccc(cc1OC1CNC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C17H18FNO2/c1-11-7-12(3-5-15(11)18)13-4-6-16(20-2)17(8-13)21-14-9-19-10-14/h3-8,14,19H,9-10H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
770n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-C...


US Patent US8575364 (2013)


BindingDB Entry DOI: 10.7270/Q2J9651G
More data for this
Ligand-Target Pair