BindingDB logo
myBDB logout

BDBM105011 US8575364, 20

SMILES: FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1

InChI Key: InChIKey=CDWBIRXEOIVBEI-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 105011   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM105011
PNG
(US8575364, 20)
Show SMILES FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C16H14F3NO/c17-16(18,19)15-7-2-1-6-14(15)11-4-3-5-12(8-11)21-13-9-20-10-13/h1-8,13,20H,9-10H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
25.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access...


US Patent US8957059 (2015)


BindingDB Entry DOI: 10.7270/Q22Z1472
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM105011
PNG
(US8575364, 20)
Show SMILES FC(F)(F)c1ccccc1-c1cccc(OC2CNC2)c1
Show InChI InChI=1S/C16H14F3NO/c17-16(18,19)15-7-2-1-6-14(15)11-4-3-5-12(8-11)21-13-9-20-10-13/h1-8,13,20H,9-10H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
25.5n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-C...


US Patent US8575364 (2013)


BindingDB Entry DOI: 10.7270/Q2J9651G
More data for this
Ligand-Target Pair