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BDBM105161 US8569281, 198

SMILES: C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3ccncc3)c12

InChI Key: InChIKey=CLWMUUVKZLAWFR-UHFFFAOYSA-N

Data: 1 KI

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 105161   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM105161
PNG
(US8569281, 198)
Show SMILES C1CC(CCO1)Oc1nccc2[nH]nc(-c3ccnc(c3)-c3ccncc3)c12
Show InChI InChI=1S/C21H19N5O2/c1-7-22-8-2-14(1)18-13-15(3-9-23-18)20-19-17(25-26-20)4-10-24-21(19)28-16-5-11-27-12-6-16/h1-4,7-10,13,16H,5-6,11-12H2,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
26n/an/an/an/an/an/an/an/a



Medical Research Council Technology; Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining Kiapp, IC50 or percent inhibition values.


US Patent US8569281 (2013)


BindingDB Entry DOI: 10.7270/Q2DN43PM
More data for this
Ligand-Target Pair