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BDBM107714 US8598210, Table XV, 20::US8722895, 20: {[5-(3-Cyanophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid::US9598370, Example 00145

SMILES: OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)[N+]#[C-]

InChI Key: InChIKey=JXJSELGVIJDMTN-UHFFFAOYSA-N

Data: 3 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 107714   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
MMDB

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Similars

US Patent
n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Vascular endothelial growth factor A


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
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US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Akebia Therapeutics, Inc.

US Patent




US Patent US9598370 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
MMDB

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US Patent
n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 190n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair