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BDBM109345 US8609666, 65

SMILES: COCCN(C)c1cc(nc2c(nc(nc12)N1CCOCC1)-c1cc(F)cc(F)c1)C(O)=O

InChI Key: InChIKey=VITMUQRGGZJLFW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109345   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM109345
PNG
(US8609666, 65)
Show SMILES COCCN(C)c1cc(nc2c(nc(nc12)N1CCOCC1)-c1cc(F)cc(F)c1)C(O)=O
Show InChI InChI=1S/C22H23F2N5O4/c1-28(3-6-32-2)17-12-16(21(30)31)25-20-18(13-9-14(23)11-15(24)10-13)26-22(27-19(17)20)29-4-7-33-8-5-29/h9-12H,3-8H2,1-2H3,(H,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.29E+3n/an/an/an/an/an/a



Merck Serono

US Patent


Assay Description
The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay. The ass...


US Patent US8609666 (2013)


BindingDB Entry DOI: 10.7270/Q26M35G5
More data for this
Ligand-Target Pair