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BDBM109346 US8609666, 66

SMILES: CN(C)c1cc(nc2c(nc(nc12)N1CCOCC1)-c1cccc(c1)C#N)C(O)=O

InChI Key: InChIKey=KWZDFAOQOJUIGM-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 109346   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM109346
PNG
(US8609666, 66)
Show SMILES CN(C)c1cc(nc2c(nc(nc12)N1CCOCC1)-c1cccc(c1)C#N)C(O)=O
Show InChI InChI=1S/C21H20N6O3/c1-26(2)16-11-15(20(28)29)23-19-17(14-5-3-4-13(10-14)12-22)24-21(25-18(16)19)27-6-8-30-9-7-27/h3-5,10-11H,6-9H2,1-2H3,(H,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Serono SA

US Patent


Assay Description
The efficacy of compounds of the invention in inhibiting the PI3K induced-lipid phosphorylation may be tested in the following binding assay. The ass...


US Patent US8609666 (2013)


BindingDB Entry DOI: 10.7270/Q26M35G5
More data for this
Ligand-Target Pair